Manufacturer: VERMODJESubstance: LetrozolePackage: 100 tabs (2.5 mg/tab)
LETROVER (Letrozole) 100 tabs (2.5 mg/tab) – Oral Steroids from VERMODJE.
Letrosol is a preparation that has an antiestrogenic effect, blocks the synthesis of estrogens (not only in peripheral but also in tumor tissues), and selectively inhibits aromatase (estrogen synthesis enzyme) by highly specific competitive binding to the subunit of this enzyme, cytochrome Р450 heme. In women in the postmenopausal period estrogens are formed mainly due to the participation of the enzyme aromatase, which converts androgens (especially testosterone and androstenedione), synthesized in adrenal-cach into estradiol and estron. Daily administration of the preparation in daily dose 0.1-5 mg shows decrease of plasma concentration of estrone, estradiol and estrone sulfate by 75-95% of initial level. Suppression of estrogen synthesis is maintained throughout the use of Letrosol. There is no disorder of steroid hormone synthesis in adrenal glands. The adrenocorticotropic mountain (ACTG) test did not reveal disorders in the synthesis of cortisol and aldherty, so additional administration of mineralocorticoids and glucocorticoids is not required. Androgens, which are precursors to estrogens, do not accumulate when the biosynthesis of estrogens is blocked. No changes in lipid profile and thyroid function, concentrates of follicle-stimulating and luteinizing hormones in blood plasma, increased frequency of strokes and myocardial infarctions were observed during the therapy period.